![]() Let's Get Movin' . Choosing a nursery, primary or secondary school and higher education. How to apply, how to appeal, how to settle your child. Tackling bullying. School run and. Paprastoji krauja. Tai daugiamet. Yra paplitusi vidutinio klimato Europoje ir Azijoje. Taip pat pasi. Skatina tul. ![]() ![]() ![]() News archive. Home > 2017 > May Monday Together for-Eva! Longoria and husband Jose Antonio Baston link arms as they wear matching navy to head to movie. The Let’s Get Movin’ programme delivers a range of healthy weight interventions for children, young people and families, to reduce BMI, improve health outcomes. Latest environmental news, features and updates. Pictures, video and more. Log in Email address Slimming World Online requires cookies to work. Your browser appears to have cookies disabled. You will be unable to log in. Is and in to a was not you i of it the be he his but for are this that by on at they with which she or from had we will have an what been one if would who has her. Create custom t-shirts and personalized shirts at CafePress. Use our easy online designer to add your artwork, photos, or text. Design your own t- shirt today! Mental health services. Mental health services are free on the NHS. You will usually need a referral from your GP to access them, although, there are some mental. ![]() ![]()
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![]() ![]() Low FODMAP diet for Irritable Bowel Syndrome. THE DIVERSITY OF NATURAL CANCER CURES. Walter Last. An amazing multitude of different cancer cures have been described in books and articles. Former cancer victims. Earlier this year (in 2012), U.S. News & World Report reported its second annual list of the Best Diets, as ranked by a panel of “22 nationally recognized experts. This site was written and created by UCLA nutrition professionals to help students eat well, be active, and feel good about their bodies. Our goal is to help prevent. The rationale for the Paleolithic diet derives from proponents' claims relating to evolutionary medicine. Advocates of the diet state that humans were.
![]() ![]() Breakfast : Gluten-free or spelt toast with vegemite, strawberry jam (sweetened with sucrose) Cereal (oats, porridge, cornflakes*, rice bubbles*). Search The College; Search Penn State Extension; Search Pennsylvania 4-H; Search Penn State; Search Penn State People; Search Penn State Departments. ![]() ![]() ![]() Pokémon GO Scavenger Hunt; A People’s Curriculum for the Earth; Professional Learning Communities at Work GM Diet. 8/8/1. 5 –We’re adding more about food to our site. Take a look and understand more about foods with Vitamin A , growing food like cucumbers and where does rice come from. Be more aware of what you eat especially when considering a new diet to assist with weight loss. Awesome Commercial Cleaning Power Without The Price, Greenwald’s. The GM Diet was created with US Department of Agriculture and Food and Drug Administration for General Motors company in the 1. ![]() We’ve broken this weight loss diet down so that it’s easy for you to follow. This diet is made for people who want to lose body fat quickly (which equals. Fiber and weight loss – what is the connection? Fiber aids weight loss by boosting satiety and also by increasing the number and varieties of good gut bacteria in. Developed for the exclusive use of General Motor employees, the secret got out and this simple seven day diet plan is now available to the public. While General Motors denies they ever developed this diet plan, the effectiveness and results seen with the system are real. Bylimiting eating to healthy, non- processed foods, the diet cleanses and invigorates the body. In seven days, it’ll help you lose ten to seventeen pounds, reset your metabolism, and get your body back on track for weight loss. What is the GM Diet Plan? This is a seven day plan that restricts eating processed and sugary foods and encourages exercise. Participants should exercise at least ten minutes a day for the duration of the plan while strictly following the eating guidelines. My Personal Experience With The GM Diet. What Can I Drink? Water is highly encouraged on the plan. Participants should drink at least ten glasses a day, fifteen on day five. For a bit of variety, participants can add lime, lemon, or cucumber to their water. Tea and coffee may be consumed without sweeteners and cream or cream substitutes. Fruit juices may only be consumed on certain days. What Can I Use When Cooking? Oil can be used in moderation. It’s recommended to restrict yourself to one teaspoon of oil a day. Herbs and spices are unlimited. Add them to whatever you like. For dressing, malt, white, and cider vinegar or vinaigrette are allowed as well as lemon and lime. Day 1. Day 2. Day 3. ![]() Day 4. Day 5. Day 6. Day 7. Fruit (raw or cooked)Potato, Baked. Fruits. Bananas. Beef. Beef. Brown Rice. Water. Butter pat. Vegetables. Skim milk. Tomatoes. Vegetables. Fruits. NO Banana. Vegetables (raw or cooked)NO Banana. GM Diet Soup. GM Diet Soup. Water. Vegetables. Water. Water. Water. Water. NO Meat. Ice. Ingredients: :Ingredients: Ingredients: Ingredients: Ingredients: Ingredients: Ingredients: Watermelon. Leaf Lettuce. Day 1 and 2 foods. Onion. Lean Ground Beef. Corn. Pineapple. Cantaloupe. Cabbage. Broccoli. Green Pepper. Beef Roast. Green Beans. Peaches. Muskmelon. Spinach. Romaine Lettuce. Tomatoes. Braised Beef tips. Kale. Pears. Papaya. Celery. Asparagus. Cabbage. Tomatoes. Red Cabbage. Baby Lettuce. Kiwi. Carrots. Green Pepper. Celery. Cherry Tomatoes. Bean Sprouts. Raisins. Mango. Cauliflower. Yellow Tomato. Cucumbers. White Asparagus. Lemon. Strawberry. Beets. Blueberry. Soy beans. Red potato. Lime. Would you try a diet that required you to eat eight bananas in one day? 7 Day General Motors Diet Plan for Weight Loss Day One: oAll fruit diet. Indian Weight Loss Blog. ![]() Orange. Cherry Tomato. Raspberry. Lentils. ![]() Peas. Collard Greens. On all days, consumption of water is encouraged to stay hydrated. Those following the plan should try to drink at least ten glasses of water a day. What about alcohol? Alcohol is forbidden during the first week of the diet. Any subsequent weeks spent following the diet allows two alcoholic beverages a week. While hard alcohol is not allowed, beer, wine, and champagne are allowed after the initial week. ![]() ![]() Can Vegetarians and Vegans Use This Plan? Absolutely! The diet can be altered for vegetarians and vegans to lose weight and feel great. Simply replace the servings of beef with beans and lentils or more brown rice. Soy milk may be used instead of skim. On day seven, vegetarians can consume two cups of brown rice. How Often Should The Plan Be Repeated? There is not a set schedule of when to repeat the diet. For those who achieve their goal weight and maintain it with healthy eating, repeating the diet once a season or twice a year may be sufficient to cleanse the body and reset healthy eating habits. For those who use the plan to jumpstart significant weight loss, repeating the diet once a month can be beneficial for eating habits and shedding pounds. Determine your weight loss goals and after the first week, decide what schedule would benefit you most. Get a weight loss buddy to work through the seven days with you. Not only will this keep you accountable but it will encourage and motivate you to finish the full seven days. What are the Benefits of the GM Diet? The General Motors diet allows participants to go through a natural cleanse by focusing on fresh produce. Processed foods, sugars, and oils are purged from your body during the seven days and this allows the body to recalibrate itself for weight loss and reduce unhealthy food cravings. While the menu is highly restricted, the simplicity of the rules for each day make following the diet simple for participants. The system also helps participants lose weight fast. While it is not intended for long term use, losing ten to seventeen pounds in a single week can help dieters gain the motivation to continue their long term weight loss goals. After completion of the diet, participants should crave sweets and processed food less and naturally gravitate to fresh fruits and vegetables for sustenance. What are the Health Risks? Like other detoxifying diets, the system may result in lightheadedness, spells of dizziness, and pangs of hunger in the early days. As with all diets, those who are pregnant or suffer from health problems should avoid this program. All others should consult their doctor to see if this plan is right for them. The diet plan is a highly restrictive seven day plan that leads to amazing results. Even those not looking to lose weight can benefit from the cleansing nature of the seven day diet. By cutting out processed foods and sugars, the body can re- acclimate to the healthy foods it should be eating. For quick weight loss or just a new perspective on eating, try this diet. See an overview of the General Motors weight loss diet program. This site is designed to give you the most comprehensive information available so that you’ll be successful in your endeavors. We hope that you enjoyed the site and please stop back and share you’re success story with us. Here’s to a skinnier you! How to Lose Weight Naturally: Proven GM Diet Plan & Exercises. Weight reduction or weight loss is of major concern in today’s world with both old and young. We all know that weight reduction was, is and will be associated to beauty, but little do we know about its importance when it comes to HEALTHCARE. Why is it that we fail to give equal importance to our health as well? Here’s an example to prove our tendency our towards weight reduction! Imagine that you have a party to attend next week and you’re just not able to fit yourself in your favourite dress. What would you do? Definitely go on serious dieting and reduce weight that’s exactly enough to get into that favourite dress of yours. And what happens after that? Back to square one and you will be all set to gobble up on anything and everything that is on the dining table. This tendency and craze for food leads to OBESITY and yet you just can’t give the up the love that you have for food. And the result is being prone to all the famous chronic diseases on earth. Obesity leads to cardiovascular (heart disease) abnormalities, diabetes and the like. The chain doesn’t stop there. Diabetes leads to renal failure and it goes on and on. Can you digest the fact that all this is because of a single dessert or a burger you can’t sacrifice? Think!! Now let’s assume that you have decided to reduce your weight? The moment you set your mind to lose weight, you want to reduce weight as fast as possible and you want to cut down at least 1. Weight loss has to be normal and natural and you have to follow steps that will help you lose weight naturally. There are two ways through which you can reduce weight naturally. When you are planning to reduce your weight through dieting, you need to follow a specific diet plan that doesn’t harm your health. There may be several diet plans that have proven great results for your friends but might not suit your physiology. Most of you would have heard of GM diet or General Motors diet. It’s a well- known diet system through which many people have reduced their weight in a healthy and natural manner. This diet system was created for the staffs of General Motors Inc and hence the name GM or General Motors diet. Though this is a well known and safe diet plan to reduce weight, not all can afford to practice it. DIABETICS and people with other health restrictions should consult your physician before practicing GM diet plan. The best part is that you lose 3- 5 kgs in 7 days. In case if you don’t experience such weight loss there’s nothing to get perturbed about it. Kindly consult with your physician. The table will explain the GM diet plan. No honey topping! Day 4. Bananas, skim milk and GM wonder soup. Indians can prefer yogurt. Increase water intake. No adding to sugar to the curd. Day 6. Veggies, paneer, and sprouts or a cup of brown rice. No tomatoes and potatoes. Day 7. Veggies, fruit juice and 2 cups of brown rice. No sugar and mayo. FREE DOWNLOAD: Printable GM Diet plan in PDF format. A Detailed explanation of the above tabular column: Day 1 of GM diet plan: Day 1 is an ALL FRUIT DAY! This can be pretty daunting on the first go, but you can choose any fruit that you would like to eat excluding bananas. You can eat how much ever you like but eat only fruits. FRUIT SALAD should be a great idea. It looks colorful and appealing and at the same time you don’t get bored of a single fruit. But no toppings on the fruit salad! Not even salt and pepper. It is very important that you consume enough of water at least 1. Water saves you from dehydration. Fruits are rich in vitamins and minerals and the fiber content in fruits help clean your digestive system. Fruits on the first day are to prepare your body for the rest of the 6 days. Day 2 of GM diet plan: Your 2nd day of GM diet plan consists only of vegetables and you are not allowed to take anything but veggies and lots of water. Choose either boiled or raw vegetables but avoid cooking in oil. High nutrient levels in vegetables are essential for your body and when you cook them in oil they don’t help in weight loss. Green leafy vegetables supply a high amount of potassium to your body. Few patients are not allowed to take potassium- rich veggies and that is why GM diet doesn’t suit people with health restrictions. In such cases, you can choose other diet plans under the guidance of your physician. Day 3 of GM diet plan: Day 3 is a combination of both day 1 and day 2 of GM diet plan. On day 3 you are allowed to take both fruits and vegetables and water goes without saying. Avoid sugar, salt and pepper to the salads. Your body will get the required amount of sugar and salt from the fruits and vegetable that you eat. NO BANANA as yet! You can switch from fruit salads to vegetable salads to avoid getting bored. Stay away from potatoes since you get enough of carbohydrates from the vegetables that are already a major part of your diet. You might be fed up of eating fruits and vegetables for all three days but no more worries. Add a pinch of salt and pepper for taste. Panner, soups and brown rice will soon become a part of your GM diet plan. Day 4 of GM diet plan: Yogurt, banana, and GM soup are your day 4 meal. Don’t confuse yogurt with curd, both are different. You can also prefer skimmed milk instead of yogurt. Yogurt and banana are the “Indian version of the Gm diet”. Buttermilk is also a good choice. But today it’s easy to get skimmed milk in the market. So it’s your choice to choose over yogurt or skim milk but don’t choose both. After three days of fruits and vegetables, you get to taste GM wonder soup and it is definitely going to be a delight to eat. But avoid cream and other rich ingredients to the soup and it should not be in a thick consistency. GM wonder soup should be watery and add a pinch of salt and pepper for taste. Not more than a pinch of salt! How to make GM wonder soup: Ingredients: Onions- 4. Capsicum . So make how much ever you might need. Once it is done, add tomatoes. Add water and let it boil nicely. Slow cook it until it the veggies become soft and tender. Add little salt and pepper for taste. Ready to serve. Day 5 of GM diet plan: Protein rich foods are a part of your diet on the 5th day. You are allowed to take curd, 5- 6 tomatoes and any one item that is rich in protein. The non- Indian version included beef in the day 5 diet plan, but the GM diet Indian version gives you an option to choose either brown rice or skinless chicken or fish. When you prefer chicken or fish, please be careful of the oil that you add to cook. It’s better if you take GRILLED fish or chicken (olive oil would be better, at least till you lose some solid amount of weight). If you prefer to follow the vegetarian version of GM diet plan and you are choosing over paneer, try and make a soup out of the tomatoes and add the paneer to it. No adding cream to the soup! Let the soup be little watery because you are dieting! You can’t fry the paneer like you do in normal cases rather saut. If you are not a paneer lover then you can choose SOYA NUGGETS. But not both!! For those who prefer brown rice, plainly boil the rice. You can’t expect the brown rice to become soft and fluffy like your white rice. Even after it’s cooked, it will not be soft. But it’s that healthy! Click on BROWN RICE and get to know about its benefits. Brown rice along with tomatoes and curd should taste good. Day 6 of GM diet plan: On this day of GM dieting, you will stay away from tomatoes. Sprouts, veggies and paneer are allotted for the 6th day of GM diet plan. Sprouts are recommended as protein supplements. You can also choose brown ice instead of sprouts. You can actually make a good salad out this combination. Drink lots of water. NO POTATOES since your body gets enough of carbohydrates from other veggies and a cup of rice. Salad Ingredients: Sprouts- handful of multigrain sprouts that include chick peas, green gram and the like or any specific sprout variety. All kind of vegetables except tomato. Paneer. Before you can start preparing your salad, here’s a word of caution. Most of you have the tendency of buying sprouts from the super markets. God knows when they are packed! So reads these steps to make your own sprouts. You can choose whatever you like to have. Step 2. Soak the grains overnight in a bowl of water. Step 3. Next morning drain the water and wash it. Step 4. Now take a pure clean cotton cloth and tightly bundle up the soaked grains in it. Step 5. After 2 days you will find the grains to have sprouted. You can also simply place the soaked grains in your refrigerator and they will still beautifully sprout. How to make the salad: Coarsely chop the veggies. You can cut them finely if you want so. Mix the veggies and sprouts. Add pepper and lemon juice for taste. You can also add little cubes of panner to it. You can also choose to make a tasty soup out of it. Day 7 of GM diet plan: The last day of your GM dieting! Veggies, rice and fruits are allotted for the 7th day. You can take even two cups of rice. For a change instead of fruit salads you can drink fruit juices. Now check your weight and you would have definitely reduced at least 3- 5 kgs. There’s nothing to worry if you haven’t reduced even less than that. Try sometime later and experience the results. It’s usually not advisable to do exercise while following the GM diet plan, at least not in the beginning stages. But regular walking is always a must for a healthy life. A word of caution: If you happened to experience severe tiredness, dehydration and the like, stop the GM diet and consult with your physician. And this the reason why we told you to confirm with your physician even before you could start with the GM diet. Now let’s make a GM diet chart so that you have a clear cut idea to get started with GM dieting. You are free to choose your favourite fruit or vegetables instead of what’s given in tabular column below. But avoid those that are excluded on respective days. Consult with your family physician before following the chart. Forget The 5: 2 Diet! Here's Why Every Other Day Dieting Is Key To Weight Loss. When people think of intermittent fasting, they tend to think of the 5: 2 diet, where people cut to a mere 5. ![]() ![]() But anyone who's ever tried it - or indeed had the displeasure of being in the general vicinity of someone who does - will be au fait with the plan's draw backs. Fast days are often plagued with hunger pangs, loss of energy and teenage mood swings. These undesirable side effects not only make the diet difficult to stick to, but could ruin the lives of your friends, family and colleagues. The solution, according to Krista Varady - the author of The Every Other Day Diet, is simple: fast more often. And she would know. The authority on intermittent fasting, Krista has worked on studies for more than 1. ![]() She featured on Michael Mosley's 'The Power Of Intermittent Fasting', the BBC programme which first popularised intermittent fasting back in 2. But, as Krista reveals, there is currently no scientific evidence to support the 5: 2 diet. All of the studies are based on the notion of intermittent fasting - ie cutting calorie intake everyotherday. I wanted the diet plan to be comprehensive and able to address questions people may have. But then the 5: 2 diet came along - claiming that all of the research pertained to 5: 2. Restrict your intake to 5. ![]() You claim dieters will eventually not feel hungry at all - can you elaborate? During our clinical studies, we measured hunger hormones (which regulate appetite and fullness). Nowadays we've lost the capacity to recognise these signs, fasting corrects the hormones and we relearn what hunger and fullness feels like. Personally, I don’t think our bodies want to eat constantly throughout the day. The body adapts to a 4. But the randomness of the 5: 2 diet (with people picking and choosing random fast days) makes it more difficult for the body to adjust. Isn't it amazing that you can lose weight in 3 days. Here is an effective & easy to implement 3 day diet, Military or AHA Three Day Diet Plan to lose weight. An overview of what the Every Other Day diet entails and where to buy the book. 1400 Calorie diet menu is my favorite because it fits majority of young women who want to be slim and fit. I used this healthy diet menu plan to lose weight myself. How do more fast days (seven per fortnight) fit into the average person's lifestyle? Weekends are generally rather sacred, are people able to stick to the diet? It can be difficult to fit The Every Other Day Diet into your social life. While we recommend that people have a 5. People tweak the diet in a way that works for them - there is no hard and fast rule. You can do two consecutive feast days, if need be. We want the diet to be flexible. Of course, sometimes fast diets simply won't suit an individual's lifestyle. And that means they may have to find something else. But I would say to give it a month before you quit, because the first week is always tough. You recommend that people eat their 5. We recommend that people consume their calories in short space of time. Simply because if you spread them out there is a higher risk of miscounting calories - People think they are eating 5. Personally I can’t eat my meal in the evenings as I can’t get through the working day without eating, so I recommend people have. Of course people tweak the diet in a way that works for them - If you do lose weight by splitting up calories into smaller meals, that's great too. Will dieters experience mood swings on fast days? After the first week people's mood should improve and crankiness should disappear. WE need to conduct more studies to find out excatly why this is - but I think it may be down to low blood sugar. Calories are where we get our energy from, so can you still exercise on the diet? Yes, you can exercise. We analysed a group of dieters at our research centre, who exercised 3 times a week. We also let people choose whether to exercise on feast or fast days, and they chose equally. During the first week participants reported low energy, but it bounces back. Some people even report more energy on fast days. It's actually advisable to exercise because you lose more weight if you do so - your muscle mass will stay high and, as a result, so will your metabolism. Participants also tended to lose more weight if they exercised in the morning, before eating. Then when their post- exercise hunger surge came (when the body is rebuilding) they would eat their 5. If you exercise after eating, you still get your hunger surge and are more likely to cheat. If dieters are allowed to eat as much as they like on non- fast days, can they really lose weight? Surprisingly one of our main discoveries was that people can’t binge on feast days when following The Every Other Day Diet - people can on 5: 2 because there is no pattern.
![]() I think it may be related to stomach shrinking or people getting in touch with their fullness cues, but we have to carry our more tests. I guess it's kind of a trick: we say . ![]() We found that both groups still lost weight and saw equal health benefits (lower blood pressure, cholesterol, insulin and glucose) and interestingly the high- fat group were less likely to cheat, as they felt more satisfied with their food. I’m a nutritionist so I still want people to eat healthily, but we want to make the diet as accessible as possible. Anyone can start the diet, all they need to manage is portion control - not go out and buy a whole new load of groceries. At our research centres we have weekly dietary and behavourial counselling to guide people towards a healthier option, educate them in nutrition and discuss weight issues. The ultimate goal is less processed food and increased fruit and vegetables intake. ![]() ![]() Pancreatic Diseases. Pancreatitis. Pancreatitis is an inflammation of the pancreas. It is often associated with early activation of digestive enzymes in the cells and ducts of the exocrine pancreas, instead of in the duodenum, that start . It usually presents with abdominal pain and can cause nausea and vomiting. Acute pancreatitis may be a single or a recurring event, and it usually occurs suddenly. The abdominal pain with acute pancreatitis is often severe. Secretions can back up in the pancreas and cause permanent damage in just a few hours. ![]() Acute pancreatitis often presents with raised levels of pancreatic enzymes in the blood. These enzymes can circulate to other body organs, causing shock and organ failure. Acute pancreatitis can lead to internal bleeding and infection and can be life- threatening. The most common cause of acute pancreatitis is blockage of the pancreatic duct (obstruction), usually due to gallstones and sometimes due to particles (sometimes tiny gallstones) in bile that have precipitated (biliary sludge). It develops gradually, often results in slow destruction of the pancreas, and can lead to other problems, such as pancreatic insufficiency (see below), bacterial infections, and type 2 diabetes. The main causes of chronic pancreatitis are gallbladder disease (ductal obstruction) and genetic risks, which are increased by modifying factors such as alcoholism. Other causes include high blood calcium level and very, very high triglyceride level, some drugs, and autoimmune conditions. Hereditary chronic pancreatitis results from mutations that affect the secretion of digestive enzymes, such as cystic fibrosis, or mutations that result from cellular changes brought on by inflammatory signals associated with repeated acute or chronic pancreatitis. Pancreatic Cancer. Read about gastritis, an inflammation of the stomach lining caused by medications, NSAIDs, aspirin, ibuprofen, H. Learn what. Biofilm Busting Protocol for H. I’d like to point out that I am not claiming that all H pylori infections can be cured by the foods listed in this article. However there is evidence in the. ![]() Liver disease skin rash - signs, symptoms and available treatment methods explained. Cancer of the pancreas is the fourth leading cause of cancer death in the United States, killing more than 3. Risks include smoking, age, sex (more common in men), chronic pancreatitis, and exposure to some industrial chemicals. About 9. 5% of pancreatic cancers develop in the exocrine tissues. Published reports attest to the high therapeutic effectiveness of various types of oils in various inflammatory processes. Pine nut oil is distinguished from other. What is a low carb diet, really? When can a low carb diet be beneficial? Should everyone follow a low carb diet? Or, can a low carb diet ruin your health? Cholesterol is a common cause of gallstones, and eating healthy, balanced gall bladder diet may help prevent stones from forming. Dissolution of the struvite stones depends on acidification of the urine through diet or urinary acidifiers. Special diets for dissolution also have reduced protein. Inflamed liver is often the first reaction that occurs in almost every type of liver disease, and is manifested through symptoms like nausea, loss of appetite and. Back to Top Treatment » Treatment involves a combination of medications to kill the H. ![]() Pancreatic cancer is very difficult to detect in the early stages because symptoms are either absent or nonspecific: abdominal pain, pruritus, nausea, loss of appetite, and sometimes jaundice. Tumors near the head section that block flow to the intestine may be detected earlier. Only about 1. 0% of the cancers are still contained within the pancreas at the time of diagnosis, which makes effective treatment very difficult. Additionally, pancreatic cancer does not respond well to current treatments. A variety of clinical studies and research efforts are being conducted on an ongoing basis to discover more effective methods. Pancreatic Insufficiency. Pancreatic insufficiency is not a primary disorder but is secondary to the other causes of pancreatic disease. It is the inability of the pancreas to produce and/or transport enough digestive enzymes to break down food in the intestine. It typically occurs as a result of progressive pancreatic damage, damage that may be caused by a variety of conditions. It is most frequently associated with cystic fibrosis in children and with chronic pancreatitis in adults; it is less frequently but sometimes associated with pancreatic cancer and other diseases that are considered to be. ![]() ![]() Before Using. Drug information provided by: Micromedex. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.Antidepressants . The choice of antidepressant medication should be based on the needs of the individual patient, however, not the small risk of a seizure or fear of drug interactions. Evidence that several antiepileptic drugs (AEDs) also function as mood stabilizers means that epilepsy and depression in some patients can be managed using one drug. AEDs such as carbamazepine or valproic acid, however, may trigger depression or mania when discontinued, and barbiturates can initiate or exacerbate depression. The risk of seizures in patients taking antidepressant drugs depends on three factors: 4. Epileptogenic effects of antidepressants. The complex neurotransmitter effects of antidepressant drugs make it impossible to offer simplistic assumptions about their proconvulsant effects. Recent experimental studies of AEDs used to treat depression lead to the conclusion that it is unlikely that alterations in serotonin and norepinephrine levels are related to an increased risk of seizures. In fact, some studies suggest that fluoxetine. By analyzing which transmitter systems are shared by proconvulsant drugs like local anesthetics, cocaine, phenothiazines, and tricyclic antidepressants, and then eliminating those with unique properties, Dailey and Naritoku concluded that it is the antihistaminic, antimuscarinic, and local anesthetic properties of antidepressants that are most likely responsible for any increased susceptibility to seizures. Even simple side effects of medication, however, such as drowsiness, can lower the seizure threshold in susceptible patients. Which antidepressants increase seizure risk the most? The overall incidence of seizures in patients taking antidepressants at reasonable doses and presumed therapeutic ranges is 0. Rochester, Minnesota. By class of drug, the highest risk of seizures has been reported with: the heterocyclic antidepressant clomipramine (0. The tricyclic antidepressants (TCAs) have the next highest seizure risk (which is increased by toxic levels). The newer selective serotonin reuptake inhibitors (SSRIs)—fluoxetine, sertraline, fluvoxamine, citalopram, and paroxetine—and serotonin receptor modulators—trazodone and nefazodone—are intermediate in risk, as is venlafaxine, a combined norepinephrine and serotonin reuptake inhibitor. ![]() Walking Corpse Syndrome or Cotard's Syndrome is a mental disorder in which patients experience delusions that they are dead, do not exist, are putrefying or have lost. Because depression is common in the general population and occurs even more often in patients with epilepsy (up to 50%, depending on the screening tool used39), and. Nursing Care of Patients taking Antidepressants. Presented By: Jennifer Meyering, RN, BSN, MS, CCRN. Approvals: This activity for 1 contact hour has. ![]() The monoamine oxidase inhibitors (MAOIs) carry the least risk. The incidence is 0. The newest agents have not been used long enough to make realistic estimates of their epileptogenic potential.
Recent estimates of seizure incidence in patients taking antidepressant drugs, based on large series of patients, have declined, implying that figures from early case series are unreliable. Some seizures in patients using SSRIs may be caused by hyponatremia due to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). SIADH has also been reported with one of the newest antidepressants, reboxetine, a norepinephrine reuptake inhibitor. Effects of antidepressant dosage and pharmacokinetics. Blood levels can be obtained for most antidepressant drugs, and these should be used to establish the steady- state baseline concentrations associated with optimal treatment effects and, in the event of a seizure, to document the associated blood level. If a toxic level is found (or at least a level higher than baseline), the antidepressant drug can generally be continued after lowering the dose. Dose- effect relationships can be informative. For example, bupropion (now used more often as an aid to smoking cessation than as treatment for depression) has a risk of seizures as high as 2. The risk is as low as 0. Seizure rates with older antidepressants, such as maprotiline or amoxapine, are now much lower than earlier estimates,3. When clomipramine is used to treat obsessive- compulsive disorder, somewhat higher dosages are used than are typically used for depression. At doses above 3. Seizures occur with severe overdoses of TCAs, just before cardiac arrest. Treatment should include alkalinization to avoid malignant arrhythmias,4 but seizures in such circumstances may be prolonged or recurrent, despite appropriate use of AEDs. At San Francisco's poison control center, overdoses of imipramine and amitriptyline accounted for 2. Massive overdoses of newer antidepressant drugs, such as fluvoxamine in doses above 1. Seizures are a neurotoxic effect of lithium and can occur even with plasma concentrations within the usual therapeutic range. EEG abnormalities are predictive of seizures. The risk of seizures is increased in elderly people, probably owing to age- related reduction in metabolism and clearance that leads to drug accumulation, despite dosages well tolerated in younger patients. Toxic amounts of antidepressant drugs also can accumulate in younger people. The active drug concentration actually within the brain is a product of many overlapping factors: variations in the amount taken by the patient, both low drug levels from poor compliance and toxic concentrations from taking more than the prescribed dose (as a result of making up missed doses, becoming confused over the dosing schedule, combining generic and branded formulations, or suicide attempts)absorption (which may vary, depending on the presence of food or antacids in the gut)degree of protein binding (which is altered by the presence of other drugs that compete for the same binding sites)transport across the blood- brain barrier (which is affected by amino acids from proteins in food)metabolic and excretory mechanisms (which may vary according to the genetically determined rate of acetylation: 5–1. CYP4. 50 enzymes)4. CYP4. 50 and glucuronyl transferase (GT) enzyme systems age (slower in the elderly. A newly emphasized property of drugs is chirality: the beneficial or toxic effects of a drug depend on its chemical . In other cases, phenytoin and carbamazepine inhibit the metabolism of antidepressant drugs, like fluoxetine or the TCAs, which leads to unintended toxicity from the antidepressant. Reference to drug interaction charts is necessary to anticipate the effects of one drug on another, as there are several isoenzymes of both the CYP4. GT systems. In general, antidepressant and antipsychotic drugs are metabolized by CYP2. D6 and CYP1. A2, the enzyme systems that also metabolize carbamazepine (See Antidepressants and their metabolizing enzymes). Most benzodiazepines and newer antipsychotic agents, as well as most other AEDs except phenytoin, use CYP3. A4. Phenytoin and a few benzodiazepines use CYP2. C9. Valproic acid is also metabolized by the glucuronyl transferase system of enzymes, as are the tricyclic drugs. Chlorpromazine and clozapine use CYP1. A3; lamotrigine, tricyclics, and clozapine use CYP1. A4; and lorazepam and most narcotic drugs use CYP2. B7. Narcotics are also metabolized by the GT1. A1 system. Drugs can induce or inhibit individual enzymes; such information is generally readily available in the Physicians' Desk Reference or other medication guides. Although it is tempting to use gabapentin and citalopram solely because of their . The choice of antidepressant medication should be based on the individual's needs rather than the fear of drug interactions or the small risk of a seizure. Seizure risk after other treatments for depression. Although isolated case reports have described spontaneous seizures after electroconvulsive therapy (ECT),5. A seizure disorder is no longer a contraindication to ECT. In patients with epilepsy who require ECT, maintenance AEDs should be withheld the day of treatment to obtain the best response. Newer technologies for treating depression, such as transcranial magnetic stimulation and vagus nerve stimulation (VNS), have not been associated with any increased risk of seizures. Adapted from: Koppel BS. Contribution of drugs and drug interactions (prescribed, over the counter, and illicit) to seizures and epilepsy. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co- existing disorders. Boston: Butterworth- Heinemann; 2. With permission from Elsevier (www. Please note that once you make your selection, it will apply to all future visits to NASDAQ.com. If, at any time, you are interested in reverting to our default. What is tapping? Millions of people are settling for lives filled with poor health and emotional baggage. Not knowing how to achieve the joyful and satisfying lives. Three years after acquiring the MIT robotics lab Boston Dynamics, makers of Atlas and other scary bots, Alphabet (Google’s parent company) is selling it off to. Here's Our First Look at Android Creator Andy Rubin's Super Hyped Secret Mystery Smartphone. After months of speculation, the creator of Android, Andy Rubin, is finally showing off his company’s new products. Since leaving Google in October 2. Today, we got our first look at it thanks to an exclusive advertisementstory from the The Verge. Behold: This is Andy Rubin’s super secret mystery phone project. The Essential Phone is powered by Android (version 7. Google Pixel and Samsung Galaxy S8. It uses the same processor as the Galaxy S8 (Qualcomm Snapdragon 8. GB of RAM and 1. 28. GB of storage. It also has a slightly bigger battery than both the Pixel and Galaxy S8 (3,0. ![]() Ah). The Essential Phone also has a nice big 5. QHD (2. 56. 0 x 1. Galaxy S8 with its edge- to- edge screen. What is EFT? It Often Works Where Nothing Else Will. First, if you haven't seen our EFT. ![]() It also has a front- facing 8- megapixel shooter capable of filming 4. K videos. That’s about as much as you could possibly ask for from the front of the device. On the backside, the Essential Phone employs dual- rear facing cameras (1. MP RGB sensor and 3- megapixel “monochrome” sensor) that will supposedly give the phone the ability to take photos comparable to its chief rivals in the i. Phone, Pixel, and Galaxy S8. It also won’t come with a headphone jack (sorry dongle haters) and will instead rely on a USB Type- C and a dongle for audio output. On paper, the phone is a beast, but since we’ve only seen official renderings and company photos—it’s hard to say whether the phone will actually live up to the hype. ![]() ![]() ![]() Update: Gary Craig retired in June 2010 and released EFT into the public domain. Gary Craig was the creator of EFT, Emotional Freedom Techniques.![]() ![]() ![]() The specs sound nice, but we’d be remiss to recommend this phone without giving it a proper trial in our everyday lives. One of the weirder elements of Essential Phone, and one we’re really looking forward to testing, is its unique inclusion of two pins on the back of the device that will make it somewhat modular and capable of hooking up to different accessories. To start, the pins are going to be used with a charging dock and 3. In the future, the pins could be used to hook up even more ambitious accessories. The Essential Phone can be reserved online starting today for $7. The Essential Phone is specifically targeting US customers and will ship in four different colors: Black Moon, Stellar Gray, Pure White, and Ocean Depths. We would suggest holding off for now, at least until we can test the device and verify that it’s actually worth a stack of hundred dollar bills. Oh, wait! But there’s more. Rubin’s company is apparently planning to release other products like the Essential Home, a smart speaker device that runs on a platform called Ambient OS that is also developed by Essential. The operating system is built specifically with a home network in mind and is meant to anticipate an owner’s every need. For example, one way the device will be more helpful than other smart speakers on the market is that it will automatically notify you to leave early for an important meeting or remind you when anniversary’s come up. The screen can be used to display timers, reminders, and even directions to upcoming meetings. The Essential Home will use a large circular display and a speaker, similar to the touchscreen Amazon Echo Show announced a couple of weeks ago. The display can apparently help you play music, search for information, set timers, and do some of the other things that you’ve come to expect from products like Google Home and Amazon Echo. The Essential Home will likely learn more skills over time through the Ambient OS API that gives developers access to devices, services, and other information about a person’s home network so that they can build more useful apps. For now, you can only pre- order the Essential Phone, and there’s no word on when the phone will begin shipping or be on sale in other places. There’s no indication of when the Essential Home will be on sale, either. We’ll certainly be following the phone’s rollout closely, but it’s safe to say Andy Rubin’s super secret phone project is.. |
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August 2017
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